FEATURES

FAMILY

ligand-gated ion channel (TC 1.A.9) family

DESCRIPTION

Also known as ACHB4_HUMAN, CHRNB4. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA (By similarity). The heteropentamer composed of alpha-3 and beta-4 subunits interacts with the alpha-conotoxin ImI (PubMed:15609996).

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EXTERNAL LINKS

CHRNB4

Neuronal acetylcholine receptor subunit beta-4

ligandability Mutations

CHRNB4

Molecular Synopsis