FEATURES

FAMILY

DESCRIPTION

Also known as AL4A1_HUMAN, ALDH4A1, ALDH4, P5CDH. Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

ALDH4A1

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

ligandability Mutations

ALDH4A1

Molecular Synopsis