ERCC5 (DNA repair protein complementing XP-G cells)

FEATURES

FAMILY

DESCRIPTION

Also known as ERCC5_HUMAN, ERCC5, ERCM2, XPG, XPGC. Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Interacts with PCNA.

... More

EXTERNAL LINKS

ERCC5

DNA repair protein complementing XP-G cells

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

ERCC5

Molecular Synopsis