FEATURES

FAMILY

DESCRIPTION

Also known as NDUS1_HUMAN, NDUFS1. Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Complex I is composed of 45 different subunits.

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EXTERNAL LINKS

NDUFS1

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

ligandability Mutations

NDUFS1

Molecular Synopsis