FEATURES

FAMILY

DESCRIPTION

Also known as PON1_HUMAN, PON1, PON. Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

PON1

Serum paraoxonase/arylesterase 1

ligandability Mutations

PON1

Molecular Synopsis