DNAJB1 logo
DNAJB1 (DnaJ homolog subfamily B member 1)
FEATURES
Loading...
Loading...
DESCRIPTION
Also known as DNJB1_HUMAN, DNAJB1, DNAJ1, HDJ1, HSPF1. Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). Interacts with DNAJC3 (PubMed:9920933). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).
Also known as DNJB1_HUMAN, DNAJB1, DNAJ1, HDJ1, HSPF1. Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrol ...
DNAJB1 logo

DNAJB1

DnaJ homolog subfamily B member 1

Interactome

DNAJB1 is reported in 7 pathways.
Provide LogoProviderPathway sizePathway name
TCR logo
NetPath 12/2011 259 TCR
Attenuation phase logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 28 Attenuation phase
HSF1 activation logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 31 HSF1 activation
HSF1-dependent transactivation logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 34 HSF1-dependent transactivation
HSP90 chaperone cycle for SHRs logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 38 HSP90 chaperone cycle for SHRs
MAPK6/MAPK4 signaling logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 91 MAPK6/MAPK4 signaling
Regulation of HSF1-mediated heat shock response logo
Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017 83 Regulation of HSF1-mediated heat shock response