FEATURES

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

DESCRIPTION

Also known as GUC2C_HUMAN, GUCY2C, GUC2C, STAR. Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

GUCY2C

Heat-stable enterotoxin receptor

ligandability Mutations

GUCY2C

Molecular Synopsis