FEATURES

FAMILY

DESCRIPTION

Also known as UBA1_HUMAN, UBA1, A1S9T, UBE1. Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). Monomer (By similarity). Interacts with GAN (via BTB domain).

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EXTERNAL LINKS

UBA1

Ubiquitin-like modifier-activating enzyme 1

ligandability Mutations

UBA1

Molecular Synopsis