FEATURES

FAMILY

succinate dehydrogenase/fumarate reductase iron-sulfur protein family

DESCRIPTION

Also known as SDHB_HUMAN, SDHB, SDH, SDH1. Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (PubMed:26749241).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SDHB

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

SDHB

Molecular Synopsis