FEATURES

FAMILY

DESCRIPTION

Also known as TA2R_HUMAN, TBXA2R. Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.

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EXTERNAL LINKS

TBXA2R

Thromboxane A2 receptor

ligandability Mutations

TBXA2R

Molecular Synopsis