TFE3 logo
TFE3 (Transcription factor E3)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as TFE3_HUMAN, TFE3, BHLHE33. Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Homodimer and heterodimer; with TFEB or MITF.
Also known as TFE3_HUMAN, TFE3, BHLHE33. Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cell ...
TFE3 logo

TFE3

Transcription factor E3

Molecular Synopsis

LIGANDABILITY
APPROVED DRUGS
No approved drugs found
INVESTIGATIONAL DRUGS
No investigational drugs found
CHEMICAL PROBES
Probe Miner logo
Chemical Probes logo
NETWORK-BASED
CANCER SCORE
OTHER DISEASES SCORE
CHEMISTRY-BASED
CHEMISTRY-BASED SCORE