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VPK1 (B1 kinase)
FEATURES
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FAMILY
DESCRIPTION
Also known as B1_VACCW, VPK1. Essential serine/threonine-protein kinase that plays different role in the viral life cycle (PubMed:1560522, PubMed:1602551). Phosphorylates the host small ribosomal protein RACK1 thereby customizing the ribosomes to a state optimal for viral mRNAs (which contain poly-A leaders) but not for host mRNAs (PubMed:28636603). Facilitates viral DNA replication by inhibiting host BANF1, a cellular host defense responsive to foreign DNA (PubMed:18005698, PubMed:1602551). Phosphorylates host BANF1 on serine and threonine residues; this leads to BANF1 relocalization to the cytoplasm, loss of dimerization and impaired DNA binding activity (PubMed:24600006). Indeed, BANF1 activity depends on its DNA-binding property which is blocked by VPK1-mediated phosphorylation (PubMed:18005698). Required for viral intermediate genes expression, probably by inhibiting host BANF1 (PubMed:11287554, PubMed:23891157). Modulates cellular responses via host JUN by two different mechanisms, either by direct phosphorylation or by modulation of upstream JIP1-MAPK complexes (PubMed:16840345). Seems to participate in the accumulation/processing of late proteins and thus in virion maturation (PubMed:26223647). Interacts with host JIP1; this interaction increases the amount of MAPK bound to JIP1 and subsequently increases the activity of transcription factors, such as JUN, that respond to these complexes.
Also known as B1_VACCW, VPK1. Essential serine/threonine-protein kinase that plays different role in the viral life cycle (PubMed:1560522, PubMed:1602551). Phosphorylates the host small ribosomal protein RACK1 thereby customizing the ribosomes to a state optimal for viral mRNAs (which contain poly-A leaders) but not for host mRNAs (PubMed:28636603) ... More
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VPK1

B1 kinase

Molecular Synopsis