FEATURES

DESCRIPTION

Also known as PLCG2_HUMAN, PLCG2. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts constitutively with THEMIS2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLCG2

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2

PLCG2

Molecular Synopsis