FEATURES

FAMILY

DESCRIPTION

Also known as MGMT_HUMAN, MGMT. Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

MGMT

Methylated-DNA--protein-cysteine methyltransferase

ligandability Mutations

MGMT

Molecular Synopsis