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rpa1 (DNA-directed RNA polymerase I subunit rpa1)
FEATURES
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FAMILY
DESCRIPTION
Also known as RPA1_SCHPO, rpa1, nuc1. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
Also known as RPA1_SCHPO, rpa1, nuc1. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A ... More
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rpa1

DNA-directed RNA polymerase I subunit rpa1

Molecular Synopsis