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(Insectotoxin-I5A)
FEATURES
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FAMILY
DESCRIPTION
Also known as CTX5A_MESEU. Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). Has been shown to weakly inhibit TRPV1 channels (PubMed:29483648).
Also known as CTX5A_MESEU. Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). Has b ... More
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Insectotoxin-I5A

Molecular Synopsis