FEATURES

FAMILY

DESCRIPTION

Also known as INSRR_HUMAN, INSRR, IRR. Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

INSRR

Insulin receptor-related protein

ligandability Mutations

INSRR

Molecular Synopsis