FEATURES

FAMILY

DESCRIPTION

Also known as T2FB_HUMAN, GTF2F2, RAP30. TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1. Interacts with GTF2B (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660).

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EXTERNAL LINKS

GTF2F2

General transcription factor IIF subunit 2

ligandability Mutations

GTF2F2

Molecular Synopsis