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B (ATP-dependent target DNA activator B)
FEATURES
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FAMILY
DESCRIPTION
Also known as TARGB_BPD10, B. Selects the target DNA sites for transposition. Recruits DDE-recombinase A to the target sites and catalytically activates it. Displays non-specific DNA-binding properties. Polymerizes as helical filaments around the DNA. Coating of the DNA by the target DNA activator B might play a role in favoring target-primed replication over integration. Prevents self-integration into an integrated copy of the viral genome. This mechanism is called target immunity and is achieved by two mechanisms: first, the target DNA activator B dissociates from the viral genome ends upon interaction in cis with DDE-recombinase A, which makes the viral genome ends a poor target for new insertions. Second, the interior of the viral genome may also ne protected from integration events by the target DNA activator B being strongly bound throughout the whole viral genome (By similarity). Homomultimer. Polymerizes in presence of ATP, preferentially on DNA. ATP hydrolysis triggers polymers dissassembly. Interacts with DDE-recombinase A; this interaction stimulates the catalytic activity of the latter as well as the ATPase activity of MuB followed by its dissociation from DNA (By similarity).
Also known as TARGB_BPD10, B. Selects the target DNA sites for transposition. Recruits DDE-recombinase A to the target sites and catalytically activates it. Displays non-specific DNA-binding properties. Polymerizes as helical filaments around the DNA. Coating of the DNA by the target DNA activator B might play a role in favoring target-primed repli ... More
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B

ATP-dependent target DNA activator B

Molecular Synopsis