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alt (NAD(+)--arginine ADP-ribosyltransferase)
FEATURES
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FAMILY
DESCRIPTION
Also known as ALT_BPT4, alt. ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region (PubMed:16112649, PubMed:173540). ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes (PubMed:11021939). Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction (PubMed:9193638, PubMed:173540). Additional in-vitro identified targets include proteins involved in either translation or cellular metabolism such as elongation factor-Tu or GroeL (PubMed:16112649). Mono-ADP-ribosylates host MAZF which may inactivate the latter (PubMed:26395283).
Also known as ALT_BPT4, alt. ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region (PubMed:16112649, PubMed:173540). ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes (PubMed:11021939). Also ribosylates RP ... More
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alt

NAD(+)--arginine ADP-ribosyltransferase

Molecular Synopsis