Prkar2a logo
Prkar2a (cAMP-dependent protein kinase type II-alpha regulatory subunit)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as KAP2_RAT, Prkar2a. Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3 (By similarity). Interacts with the phosphorylated form of PJA2 (By similarity). Interacts with MYRIP; his interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. Forms a complex composed of PRKAR2A, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (By similarity). Interacts with ADCY8; inhibits adenylate cyclase activity through PKA phosphorylation (By similarity).
Also known as KAP2_RAT, Prkar2a. Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation b ... More
Prkar2a logo

Prkar2a

cAMP-dependent protein kinase type II-alpha regulatory subunit

Molecular Synopsis