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Pol (LINE-1 retrotransposable element ORF2 protein)
FEATURES
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DESCRIPTION
Also known as LORF2_MOUSE, Pol, Gm17492. Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. Interacts with MOV10.
Also known as LORF2_MOUSE, Pol, Gm17492. Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' str ... More
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Pol

LINE-1 retrotransposable element ORF2 protein

Molecular Synopsis