PNMT logo
PNMT (Phenylethanolamine N-methyltransferase)
FEATURES
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FAMILY
DESCRIPTION
Also known as PNMT_HUMAN, PNMT, PENT. Converts noradrenaline to adrenaline.
Also known as PNMT_HUMAN, PNMT, PENT. Converts noradrenaline to adrenaline.
PNMT logo

PNMT

Phenylethanolamine N-methyltransferase

Germline Genetics

Summary of germline evidence for PNMT and cancer

  • Ensembl Gene ID: ENSG00000141744
  • Ensembl Transcript ID/s: ENST00000269582
  • Entrez Gene ID: 5409
  • HGNC Gene Symbol: PNMT

Genome-wide association studies

PNMT maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
1330_rs8067378 17q21.1 38051348 rs8067378-G 0.22 9E-10 1.19 [1.13-1.26] Cervical cancer 23817570 https://www.ebi.ac.uk/gwas/search?query=rs8067378 17:36820000-38180000 r2>0.4 (17:37824339-38126231) -
1884_rs2290400 17q21.1 38066240 rs2290400-T NR 1E-9 1.17 [1.11-1.23] Acute lymphoblastic leukemia (childhood) 29348612 https://www.ebi.ac.uk/gwas/search?query=rs2290400 17:36820000-38180000 r2>0.3 (17:37767453-38215117) -