FEATURES

DESCRIPTION

Also known as CAP13_FLASX, cap13. CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type I-D(GG) CBASS system (PubMed:32839535)., Binds cyclic dinucleotides: binds c-di-GMP (synthesized by the cognate CdnE encoded upstream in the same operon), cyclic 3'3'-cyclic GMP-AMP (3'3'-cGAMP) but not cUMP-AMP (PubMed:32877915). The effector protein for this CBASS system, its activity is stimulated by c-di-GMP and leads to cell death (Probable). Homodimer.

EXTERNAL LINKS

cap13

CD-NTase-associated protein 13

cap13

Molecular Synopsis