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TMK (Thymidylate kinase)
FEATURES
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FAMILY
DESCRIPTION
Also known as KTHY_VARV, TMK. Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity). Homodimer; the dimer arrangement is orthogonal and not antiparallel as in human enzyme.
Also known as KTHY_VARV, TMK. Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By simila ... More
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TMK

Thymidylate kinase

Molecular Synopsis