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(Thrombin-like enzyme Cdc SI)
FEATURES
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FAMILY
DESCRIPTION
Also known as VSP1_CRODM. Thrombin-like snake venom serine protease that coagulates human plasma and bovine fibrinogen by hydrolysis of the alpha chains (FGA) (minimum coagulation dose is 120 ug on fibrinogen). Has fibrinogenolytic activities, and degrades preferentially the Aalpha chain (FGA). Shows amidolytic activity toward N-benzoyl-L-Arg-p-nitroanilide, has a lower activity than Cdc SII. In vivo, intravenous injection induces defibrin(ogen)ation and a loss of the righting reflex and opisthotoxins, together with a typical gyroxin-like effect (18-20 minutes). Subcutaneous injection into the footpads induces moderate edema. Potentiates local hemorrhagic activity induced by metalloproteinases (BaP1). Monomer.
Also known as VSP1_CRODM. Thrombin-like snake venom serine protease that coagulates human plasma and bovine fibrinogen by hydrolysis of the alpha chains (FGA) (minimum coagulation dose is 120 ug on fibrinogen). Has fibrinogenolytic activities, and degrades preferentially the Aalpha chain (FGA). Shows amidolytic activity toward N-benzoyl-L-Arg-p-nit ... More
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Thrombin-like enzyme Cdc SI

Molecular Synopsis