3L22E (Alpha-elapitoxin-Aa2e)

FEATURES

FAMILY

DESCRIPTION

Also known as 3L22E_ACAAN, 3L22E. Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (By similarity). Produces paralysis, clear dyspnea and lethality on mice (PubMed:9133710).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

3L22E

Alpha-elapitoxin-Aa2e

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

3L22E

Molecular Synopsis