FPR4 (FK506-binding protein 4)

FEATURES

FAMILY

DESCRIPTION

Also known as FKBP4_CRYNJ, FPR4. PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression. Binds to histones H3 and H4.

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

FPR4

FK506-binding protein 4

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

FPR4

Molecular Synopsis