FEATURES

FAMILY

DESCRIPTION

Also known as NANA_ECOLI, nanA, npl. Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate (PubMed:1646603). Experiments show the true substrate is aceneuramate (linearized Neu5Ac), which forms spontaneously at alkaline pH. Linear aceneuramate can be provided by NanQ (PubMed:33895133). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

nanA

N-acetylneuraminate lyase

nanA

Molecular Synopsis