FURIN logo
FURIN (Furin)
FEATURES
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FAMILY
DESCRIPTION
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999)., (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins., (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin., (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (PubMed:11331585).
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an e ...

Interactome

FURIN is reported in 28 pathways.
Provide LogoProviderPathway sizePathway name
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 236 Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Notch secretory pathway ( Notch signaling pathway Diagram ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 5 Notch secretory pathway ( Notch signaling pathway Diagram )
Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 5 Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram )
Notch secretory pathway (Drosophila) ( Notch signaling pathway Diagram ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 1 Notch secretory pathway (Drosophila) ( Notch signaling pathway Diagram )
Notch secretory pathway (Mammal) ( Notch signaling pathway Diagram ) logo
INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011 2 Notch secretory pathway (Mammal) ( Notch signaling pathway Diagram )
Cellular roles of Anthrax toxin logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 22 Cellular roles of Anthrax toxin
Glypican 3 network logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 9 Glypican 3 network
HIF-1-alpha transcription factor network logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 67 HIF-1-alpha transcription factor network
Notch signaling pathway logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 58 Notch signaling pathway
p75(NTR)-mediated signaling logo
NCI Curated Human Pathways from PID (final); 27-Jul-2015 74 p75(NTR)-mediated signaling