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FURIN (Furin)
FEATURES
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FAMILY
DESCRIPTION
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999)., (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins., (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin., (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (PubMed:11331585).
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an e ...

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.45 2.25 2.15 2.05 1.82 126 2.38 2.12 2.06 2.01 -0.09 0.09
Bladder (BLCA) 406 3.29 2.40 2.30 2.19 1.57 9 2.24 2.20 2.17 2.11 2.09 0.12
Breast (BRCA) 1067 3.09 2.26 2.13 2.03 1.34 178 2.69 2.34 2.20 2.10 1.82 -0.06
Cervical (CESC) 297 3.23 2.37 2.24 2.10 1.34 10 2.25 2.16 2.11 2.10 2.02 0.13
Cholangiocarcinoma (CHOL) 36 3.44 2.61 2.48 2.36 1.96 0
Colon (COAD) 443 3.05 2.38 2.28 2.16 1.31 166 2.43 2.20 2.15 2.09 -0.09 0.12
B-cell lymphoma (DLBC) 42 2.63 2.26 2.10 1.93 1.67 337 3.85 3.20 3.02 2.80 2.21 -0.92
Esophageal (ESCA) 142 2.74 2.37 2.24 2.15 1.83 271 2.55 2.21 2.14 2.08 -0.09 0.10
Glioblastoma (GBM) 160 2.42 2.04 1.92 1.85 1.52 214 2.36 2.13 2.09 2.04 -0.09 -0.17
Head and neck (HNSC) 432 2.93 2.54 2.44 2.33 1.87 55 2.54 2.38 2.32 2.24 2.05 0.12