FURIN logo
FURIN (Furin)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999)., (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins., (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin., (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (PubMed:11331585).
Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an e ...

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 146 1.00
NS 0 0 0 152 1.02
carcinoma 2 2 1.95 0 549 1.02
haematopoietic_neoplasm 0 0 0 63 1.03
leukaemia 0 0 0 84 1.02
lymphoid_neoplasm 0 0 0 135 1.03
glioma 0 0 0 52 1.01
malignant_melanoma 0 0 0 56 1.09
melanoma 0 0 0 43 1.11
glioblastoma 0 0 0 2 0.97

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 4 3.09 1.29 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid