FEATURES

FAMILY

DESCRIPTION

Also known as ADA2A_HUMAN, ADRA2A, ADRA2R, ADRAR. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

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EXTERNAL LINKS

ADRA2A

Alpha-2A adrenergic receptor

ligandability Mutations

ADRA2A

Molecular Synopsis