IGF2R (Cation-independent mannose-6-phosphate receptor)

FEATURES

FAMILY

DESCRIPTION

Also known as MPRI_BOVIN, IGF2R, M6P. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Binds HA-I and HA-II plasma membrane adapters (PubMed:2545438). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 (By similarity). Interacts with the heterotrimeric retromer cargo-selective complex (CSC), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (By similarity).

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EXTERNAL LINKS

IGF2R

Cation-independent mannose-6-phosphate receptor

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

IGF2R

Molecular Synopsis