ERCC1 (DNA excision repair protein ERCC-1)

FEATURES

FAMILY

DESCRIPTION

Also known as ERCC1_HUMAN, ERCC1. Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4., Not functional in the nucleotide excision repair pathway., Not functional in the nucleotide excision repair pathway., Not functional in the nucleotide excision repair pathway. Heterodimer composed of ERCC1 isoform 1 and ERCC4/XPF (PubMed:16076955, PubMed:16338413, PubMed:24036546, PubMed:25538220). Interacts with USP45 (PubMed:25538220).

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EXTERNAL LINKS

ERCC1

DNA excision repair protein ERCC-1

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

ERCC1

Molecular Synopsis