MOD5 (tRNA dimethylallyltransferase)

FEATURES

FAMILY

DESCRIPTION

Also known as MOD5_YEAST, MOD5. Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP).

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EXTERNAL LINKS

MOD5

tRNA dimethylallyltransferase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

MOD5

Molecular Synopsis