LmjF06.0860, LmjF_06_0860 (Bifunctional dihydrofolate reductase-thymidylate synthase)

FEATURES

DESCRIPTION

Also known as DRTS_LEIMA, LmjF06.0860, LmjF_06_0860. Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

LmjF06.0860, LmjF_06_0860

Bifunctional dihydrofolate reductase-thymidylate synthase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

LmjF06.0860, LmjF_06_0860

Molecular Synopsis