UL48 (Tegument protein VP16)

FEATURES

FAMILY

herpesviridae tegument protein VP16 protein family

DESCRIPTION

Also known as VP16_HHV11, UL48. Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection., May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis. Interacts with VP22. Interacts with gH (via C-terminus). Interacts with the virion host shutoff protein (vhs). Interacts with VP11/12. Associates with the VP16-induced complex; binding to host HCFC1 activates VP16 for association with the octamer motif-binding host protein POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.

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EXTERNAL LINKS

UL48

Tegument protein VP16

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

UL48

Molecular Synopsis