SUP35 (Eukaryotic peptide chain release factor GTP-binding subunit)

FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as ERF3_YEAST, SUP35, GST1, PNM2, SAL3, SUF12, SUP2. Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening. Heterodimer of two subunits, one of which binds GTP. Interacts with polyadenylate-binding protein PAB1, and TPA1.

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EXTERNAL LINKS

SUP35

Eukaryotic peptide chain release factor GTP-binding subunit

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

SUP35

Molecular Synopsis