alkB (Alpha-ketoglutarate-dependent dioxygenase AlkB)

FEATURES

FAMILY

DESCRIPTION

Also known as ALKB_ECOLI, alkB, aidD. Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

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EXTERNAL LINKS

alkB

Alpha-ketoglutarate-dependent dioxygenase AlkB

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

alkB

Molecular Synopsis