tyrB (Aromatic-amino-acid aminotransferase)

FEATURES

FAMILY

class-I pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as TYRB_ECOLI, tyrB. Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S, 3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085. Homodimer.

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EXTERNAL LINKS

tyrB

Aromatic-amino-acid aminotransferase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

tyrB

Molecular Synopsis