MAS1 (Proto-oncogene Mas)

FEATURES

FAMILY

DESCRIPTION

Also known as MAS_HUMAN, MAS1, MAS. Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

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EXTERNAL LINKS

MAS1

Proto-oncogene Mas

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

MAS1

Molecular Synopsis