FEATURES

FAMILY

paramyxoviruses fusion glycoprotein family

DESCRIPTION

Also known as FUS_HRSVA, F. Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins., Class I viral fusion protein (PubMed:23618766). Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state (PubMed:23618766). During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain (PubMed:23618766, PubMed:19966279). The formation of this structure appears to drive apposition and subsequent fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm (PubMed:23593008, PubMed:23618766). This fusion is pH independent and occurs at the plasma or endosomal membrane (Probable). The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate (PubMed:10864656). F protein is involved in the entry into the host cell through the interaction with host IGFR1 (PubMed:32494007). This interaction activates PRKCZ/PKCzeta that recruits host NCL/nucleolin to the apical cell surface where it can bind fusion glycoprotein F1 (PubMed:32494007, PubMed:21841784). Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (PubMed:10438814). F protein may trigger p53-dependent apoptosis (PubMed:18216092)., Major determinant of the species specificity of RSV infection (PubMed:12663767). The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate (PubMed:10864656). F protein is involved in the entry into the host cell through the interaction with host IGFR1 (PubMed:32494007). This interaction activates PRKCZ/PKCzeta that recruits host NCL/nucleolin to the apical cell surface where it can bind fusion glycoprotein F1 (PubMed:32494007). Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (PubMed:10438814). F protein seems to trigger p53-dependent apoptosis (PubMed:18216092). Homotrimer (PubMed:23618766, PubMed:26333350). Heterodimer with fusion protein F2; disulfide-linked (PubMed:16723026, PubMed:21613394). Interacts with host NCL; this interaction plays a role in viral entry into the host cell (PubMed:21841784). As a heterodimer with F2, interacts with host heparan sulfate (PubMed:10864656). As a heterodimer with F2, interacts with host IGFR1; this interaction activates PRKCZ/PKCzeta that recruits NCL/nucleolin from the host nucleus to the plasma membrane (PubMed:32494007). Part of a complex composed of F1, F2 and G glycoproteins (PubMed:18036342). As a heterodimer with F2, interacts with host RHOA; this interaction facilitates virus-induced syncytium formation (PubMed:10438814).

EXTERNAL LINKS

F

Fusion glycoprotein F0

F

Molecular Synopsis