FEATURES

FAMILY

DESCRIPTION

Also known as GCN4_YEAST, GCN4, AAS101, AAS3, ARG9. Master transcriptional regulator that mediates the response to amino acid starvation (PubMed:11390663, PubMed:29628310). Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions (PubMed:29628310, PubMed:11390663, PubMed:1473154, PubMed:2277632, PubMed:1939099, PubMed:7664107, PubMed:2204805, PubMed:3678204, PubMed:3532321, PubMed:3530496). During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors (PubMed:11390663, PubMed:29628310, PubMed:8336737, PubMed:1939099, PubMed:10733573, PubMed:7862116). Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters (PubMed:19940160, PubMed:9488488, PubMed:10549298). Homodimer (PubMed:1473154, PubMed:3678204). Each subunit binds overlapping and non-identical half-sites that flank the central CG base-pair in the pseudo-palindromic motif 5'-ATGA[CG]TCAT-3' (PubMed:1473154, PubMed:7664107, PubMed:2204805, PubMed:3678204). Interacts with the mediator tail; the interaction with GAL11/MED15 is direct (PubMed:19940160, PubMed:9488488, PubMed:10549298). Interacts with the SAGA histone acetyltransferase complex (PubMed:19940160, PubMed:9488488, PubMed:10549298). Interacts with the SWI/SNF chromatin remodeling complex (PubMed:19940160, PubMed:10549298).

Also known as GCN4_YEAST, GCN4, AAS101, AAS3, ARG9. Master transcriptional regulator that mediates the response to amino acid starvation (PubMed:11390663, PubMed:29628310). Binds variations of th ...

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EXTERNAL LINKS

GCN4

General control transcription factor GCN4

GCN4

Molecular Synopsis