KRAS logo
KRAS (GTPase KRas)
FEATURES
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FAMILY
DESCRIPTION
Also known as RASK_HUMAN, KRAS, KRAS2, RASK2. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (PubMed:23698361). Interacts with SOS1 (PubMed:22431598).
Also known as RASK_HUMAN, KRAS, KRAS2, RASK2. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC ...

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.25 1.94 1.86 1.75 1.46 126 1.90 1.77 1.74 1.70 -0.09 0.12
Bladder (BLCA) 406 3.16 1.99 1.90 1.82 1.41 9 2.07 1.93 1.84 1.82 1.73 0.06
Breast (BRCA) 1067 2.73 2.01 1.92 1.83 1.40 178 1.97 1.79 1.72 1.68 1.52 0.20
Cervical (CESC) 297 2.85 1.99 1.92 1.85 1.35 10 2.04 1.86 1.76 1.67 1.53 0.16
Cholangiocarcinoma (CHOL) 36 2.04 1.92 1.86 1.80 1.61 0
Colon (COAD) 443 2.68 2.04 1.95 1.86 1.39 166 2.25 2.01 1.93 1.87 -0.09 0.02
B-cell lymphoma (DLBC) 42 2.27 2.04 1.88 1.77 1.58 337 2.52 2.22 2.12 2.03 1.52 -0.24
Esophageal (ESCA) 142 3.27 2.10 2.00 1.91 1.63 271 2.32 2.06 2.01 1.93 -0.09 -0.01
Glioblastoma (GBM) 160 2.08 1.80 1.76 1.69 1.44 214 2.29 1.92 1.84 1.77 -0.09 -0.08
Head and neck (HNSC) 432 2.81 2.03 1.95 1.87 1.43 55 2.13 1.88 1.84 1.79 1.64 0.11