FEATURES

FAMILY

DESCRIPTION

Also known as ANT3_HUMAN, SERPINC1, AT3. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Forms protease inhibiting heterodimer with TMPRSS7.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

SERPINC1

Antithrombin-III

ligandability Mutations

SERPINC1

Molecular Synopsis