FEATURES

FAMILY

DESCRIPTION

Also known as HCN2_MOUSE, Hcn2, Bcng2, Hac1. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Homotetramer. Heterotetramer with HCN1. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2.

EXTERNAL LINKS

uniprot
enzyme classification

Hcn2

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Mutations

Mutation(s) distribution

Mutations table

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