Dnmt3a (DNA (cytosine-5)-methyltransferase 3A)

FEATURES

FAMILY

DESCRIPTION

Also known as DNM3A_MOUSE, Dnmt3a. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L). Interacts with DNMT1 and DNMT3B. Interacts with MPHOSPH8. Interacts with histone H3 that is not methylated at 'Lys-4' (H3K4) (By similarity). Binds the ZBTB18 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD domain. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9, PIAS1 and PIAS2 (PubMed:14752048). Interacts with SPOCD1 (PubMed:32674113).

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EXTERNAL LINKS

Dnmt3a

DNA (cytosine-5)-methyltransferase 3A

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Molecular Synopsis
Structural Ligandability

Dnmt3a

Structural Ligandability

Domains Chains

Distribution