pikC (Cytochrome P450 monooxygenase PikC)

FEATURES

FAMILY

DESCRIPTION

Also known as PIKC_STRVZ, pikC, picK. Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.

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EXTERNAL LINKS

pikC

Cytochrome P450 monooxygenase PikC

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

pikC

Molecular Synopsis