FEATURES

FAMILY

mitochondrial carrier (TC 2.A.29) family

DESCRIPTION

Also known as CMC1_HUMAN, SLC25A12, ARALAR1. Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871). Homodimer (via N-terminus).

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

SLC25A12

Calcium-binding mitochondrial carrier protein Aralar1

ligandability Mutations

SLC25A12

Molecular Synopsis